ZIN2-SYSTEM
The Tuner of Light and DarknessZIN2-TrustProof™ Analysis Service
Currently under soft launch.
We offer free peptide sequence analysis, toxicity prediction, and ingredient validation as part of our pilot program.
A system trusted by science, created for the future.
Our Analysis Scope
AI-based peptide folding stability, mutation impact & integrated safety profiling.
Simulation of compound interactions & bioavailability for optimized formulations.
Structure-driven forecasting of efficacy pathways & long-term outcome simulation.
Development potential scoring with regulatory and market applicability.
Why ZIN2?
In a world where ingredient claims often lack scientific rigor,
ZIN2 introduces a framework of
logic, structured analysis,
and predictive simulation — validating what others cannot quantify.
We don’t just analyze — we
prove,
simulate, and
forecast
effects before they manifest, creating
a new paradigm of evidence-driven innovation.
🔬 SALA System-Based Derivative Research Report
RootLaw Structural Re-Analysis & Functional Upgrade of Astaxanthin
📌 Research Subject: Astaxanthin
📄 Request Summary:
Client requested a SALA System evaluation of Astaxanthin with focus on RootLaw-driven optimization,
predictive safety validation, and whether a derivative with enhanced stability, penetration, and long-term resilience could be proposed.
🧬 SALA Applied Workflow:
- RootLaw trigger-variable extraction
- WindTrace Core simulation for oxidative & photo-aging stress
- TrustProof™ validation loop (safety, regulatory thresholds)
- Predictive modeling of derivative candidates (ROS resilience, dermal delivery, bioavailability)
🔎 Structural Analysis Summary:
Astaxanthin’s antioxidant trigger zones were confirmed, but SALA highlighted constraints:
ROS vulnerability, low penetration depth, and instability under UV stress.
RootLaw decomposition pinpointed critical modification zones (C4, C10, terminal rings).
💡 SALA-Predicted Enhancements:
- Bioavailability: ~2.8× increase via stabilized esterified C4-hydroxy substitution
- Penetration: Improved with amphiphilic C10-alkyl–peptide hybrid side chain
- ROS Resilience: +42% via terminal thioether + antioxidant loop integration
- UV Stability: Enhanced by WindTrace Core–guided dual-ring reinforcement
🚀 Proposed SALA-Derived Compound:
Name: SALA-AstaRegenX™
Structure: RootLaw-enhanced esterified base + amphiphilic side chain + thioether-stabilized ring
Advantages: Superior dermal absorption, ROS defense, and photo-stability
🧪 Structural Composition:
| Component | Description |
|---|---|
| Base Scaffold | RootLaw-esterified C4-hydroxy astaxanthin |
| Functional Booster | C10 amphiphilic alkyl–peptide side chain |
| ROS Enhancer | Thioether-substituted terminal ring with antioxidant feedback loop |
| Delivery System | Liposome + peptide-assisted micelle hybrid |
| Stabilizer | WindTrace Core–guided UV shield integration |
📊 SALA Predictive Simulation Results
- • ROS Reduction Efficiency: +42%
- • Skin Penetration: +145%
- • Bioavailability: 2.8×
- • UV Stability: +75%
🧾 Conclusion:
The SALA System has refined Astaxanthin analysis using RootLaw and TrustProof validation,
delivering a structurally optimized derivative — SALA-AstaRegenX™,
projected to outperform the original in bioavailability, penetration, antioxidant power, and UV resilience.
Silymarin
📌 Function: Liver-protective botanical compound with antioxidant & detox properties
🔬 ZIN2 Analysis Highlights:
- Predictive modeling of bioavailability under metabolic stress
- Structural flow & metabolite pathway prediction
- Synergy scoring with antioxidant clusters (flavonoids, polyphenols)
- Simulation of botanical absorption barriers in gut & liver tissues
EGF (Epidermal Growth Factor)
📌 Function: Key peptide for skin regeneration, wound healing, and growth signaling
🔬 ZIN2 Analysis Highlights:
- Receptor-binding affinity prediction & validation mapping
- Stability simulation under oxidative & enzymatic skin microenvironment
- Synergistic potential with matrix peptides & growth factors
- Compatibility analysis with advanced delivery systems (liposome, micelle, hydrogel)
🔬 SALA System-Based Derivative Research Report
🧬 Structural Evaluation and Functional Enhancement of GHK-Cu
📌 Research Subject: GHK-Cu (glycyl-L-histidyl-L-lysine) copper tripeptide
📄 Request Summary:
Client requested structural optimization and permeability enhancement while preserving ECM regeneration potential.
🧬 SALA System Applied Workflow:
- Conflict Variable Resolution: histidine–Cu²⁺ coordination stability handled up front
- Repetition-Free Pathway: redundant cascade simulations skipped → faster convergence
- ScenarioDrive: alternative diffusion & receptor-proximal uptake routes auto-evaluated
- OriginTrace: all improvements mapped to trigger zones (imidazole ring, N-terminal region)
🔎 Structural Analysis Summary:
SALA confirmed the histidine imidazole as the critical Cu²⁺ coordination site. Native GHK-Cu shows limited keratinocyte penetration
and susceptibility to enzymatic degradation. By focusing only on the conflict variables (coordination stability, cutaneous uptake,
and protease exposure), SALA identified a small set of high-leverage modifications that raise signaling persistence without
compromising the core motif.
💡 SALA-Predicted Enhancements:
- Acylated Lys side-chain tuning → improved skin retention with minimal bulk
- Polar micro-environment adjustment around His → higher Cu²⁺ binding resilience
- Flexible linker (PEG-like) → extended ECM signaling duration with fewer cycles
- SALA efficiency: convergence achieved 35% faster than prior baseline
🧪 SALA-GHK-Cu-Derived Composition:
| Component | Description |
|---|---|
| Peptide Core | GHK motif with stabilized His–Cu²⁺ interaction |
| Modified Linker | PEG-like flexible spacer to enhance diffusion |
| Retention Tuner | Acylated Lys side-chain for balanced skin residence |
| SALA Efficiency Tag | Reduced redundancy via conflict-first re-simulation |
📊 SALA Predictive Simulation Results
- • Skin Penetration: +126%
- • Cu²⁺ Binding Stability: +49%
- • Signal Duration: +2.2×
- • ROS Suppression: +57%
- • Efficiency Gain: –35% simulation cycles
🧾 Conclusion:
The SALA system refined GHK-Cu by stabilizing His–Cu²⁺ coordination and prioritizing conflict variables,
achieving stronger dermal uptake and longer ECM signaling with fewer simulation cycles. The derivative exhibits
clear advantages for next-gen anti-aging and dermal repair applications while preserving the peptide’s core behavior.
L-Carnitine
📌 Function: Essential compound for fat metabolism, mitochondrial transport, and energy regulation
🔬 ZIN2 Analysis Highlights:
- Simulation of fatty acid transport across mitochondrial membrane
- Predictive modeling of metabolic side-effect deviations
- Time-release & bioavailability optimization
- Interaction mapping with energy metabolism pathways
